Amlodipine is one of the most prescribed blood pressure medications worldwide — effective, once-daily dosing, and well-tolerated by most patients.
Amlodipine is a dihydropyridine calcium channel blocker (CCB) that relaxes and dilates blood vessels by blocking calcium ions from entering vascular smooth muscle cells. This vasodilatory effect reduces blood pressure and relieves angina (chest pain from insufficient coronary blood flow). It is one of the most widely prescribed antihypertensives globally and features on the WHO's List of Essential Medicines.
In Korea, amlodipine is prescribed by GPs and cardiologists for hypertension (high blood pressure) and stable angina. It is particularly valuable in patients who also have diabetes or chronic kidney disease, as it is nephroprotective and improves outcomes in these groups. The typical starting dose is 5mg once daily, which can be titrated to 10mg. Blood pressure should be monitored at home and at local clinic check-ups to assess response — the target is typically <140/90 mmHg for most adults, <130/80 for diabetics.
The most common side effect of amlodipine is peripheral oedema (ankle and leg swelling) — caused by the vasodilation allowing fluid to leak into tissues. This affects up to 15% of patients at higher doses and is more common in hot, humid climates like Korea's summer. It is generally benign but can be uncomfortable. Dose reduction or switching to a different CCB may help. Other side effects include headache, flushing, and dizziness — usually mild and often temporary. Amlodipine is safe in pregnancy (Category C) and is used when blood pressure control is essential and other options are less suitable.
Key Points
- Once-daily dosing — take at the same time each day for consistent blood pressure control
- Ankle swelling is the most common side effect — especially in Korea's summer heat
- Do not stop suddenly — blood pressure may rebound
- Safe in kidney disease and diabetes
- Avoid grapefruit juice with amlodipine
- Monitor blood pressure at home between GP visits
When to See a Doctor
- Severe ankle swelling or bilateral leg oedema
- Blood pressure not controlled on amlodipine alone
- Dizziness or fainting — possible over-treatment
- Chest pain worsening — angina management review
For emergencies in Korea, call 119
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This article is published by DoctorsInKorea.com for educational and informational purposes only. It does not replace a professional clinical evaluation by a licensed healthcare provider. For accurate medical diagnosis and personalised treatment paths, please book an appointment with a licensed KMA physician. For immediate life-threatening medical emergencies in Korea, please call 119.
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Last reviewed: March 1, 2025